From time to time the European Commission (EC) is accused of unfairly targeting U.S. companies in its antitrust scrutiny. Competition Commissioner Margrethe Vestager was quick to reject this suggestion last year and already in 2016 has been in front of U.S. media to reiterate that this is not the case. Our quick look at cases involving U.S. companies reveals a nuanced picture. Sectors currently of interest to the EC are populated by U.S. companies, bringing them into the EC’s spotlight. However, although some face serious antitrust risks, others are benefiting from positive support or even escaping adverse finding.