Often, the same conduct triggers overlapping antitrust investigations or litigation in different jurisdictions over many years. In this complex environment, developing and implementing a successful settlement strategy can be daunting. Without careful planning, it is difficult for target companies to manage overall global financial exposure, or to minimise settlement disclosures and admissions that could be harmful in future related matters. Each chapter in this Guide explores these problems in greater depth, and in different jurisdictions. We begin here with a discussion of overarching questions to consider when developing a successful master settlement strategy across multiple enforcers, claimants or countries.