In this chapter of the fourth edition of Global Competition Review’s Merger Remedies Guide, Analysis Group consultants analyze the design of merger remedies to address potential anticompetitive effects of mergers and explore the evolving merger remedies landscape from the perspectives of practitioners and regulators. CEO and Chairman Martha S. Samuelson and Managers Ishita Rajani and Alex Robinson examine key economic issues considered by US antitrust agencies in the selection and design of merger remedies for horizontal and vertical mergers. The authors discuss recent developments in the design of merger remedies as agencies balance protecting pre-merger competition and a merger’s efficiency-enhancing potential, while avoiding unnecessary restraints on competition. The authors draw on case studies to illustrate applications of merger remedies in an environment of evolving industry structures, competitive dynamics, and antitrust considerations.